| Date | Opponent | Location | Time (CT)/Result | |  | | Feb. 17, 2010 | McNeese State (Game 1) | Husky Field | 5-3 W | Recap | Box | | Feb. 17, 2010 | McNeese State (Game 2) | Husky Field | 0-5 L | Recap | Box | | Feb. 19, 2010 | @ Prairie View A&M (Game 1) | Prairie View | (5 inn.) 18-1 W | Recap | Box | | Feb. 19, 2010 | @ Prairie View A&M (Game 2) | Prairie View | 3-0 W | Recap | Box | | Feb. 24, 2010 | Stephen F. Austin State | Husky Field | 1-5 L | Recap | Box | | Feb. 25, 2010 | @ Texas A&M-Corpus Christi (Holiday Inn Emerald Beach Invitational) | Corpus Christi | 2-6 L | Recap | Box | | Feb. 26, 2010 | Louisiana at Monroe (Holiday Inn Emerald Beach Invitational) | Corpus Christi | 0-2 L | Recap | Box | | Feb. 26, 2010 | North Dakota (Holiday Inn Emerald Beach Invitational) | Corpus Christi | 0-6 L | Recap | Box | | Feb. 27, 2010 | North Dakota (Holiday Inn Emerald Beach Invitational) | Corpus Christi | 6-4 W | Recap | Box | | Feb. 27, 2010 | Louisiana at Monroe (Holiday Inn Emerald Beach Invitational) | Corpus Christi | (5 inn.) 0-8 L | Recap | Box | | Mar. 3, 2010 | @ Texas Tech (Game 1) | Lubbock | 1-4 L | Recap | Box | | Mar. 3, 2010 | @ Texas Tech (Game 2) | Lubbock | (5 inn.) 0-8 L | Recap | Box | | Mar. 6, 2010 | UH-Victoria (Game 1) | Husky Field | 4-0 W | Recap | Box | | Mar. 6, 2010 | UH-Victoria (Game 2) | Husky Field | 2-3 L | Recap | Box | | Mar. 10, 2010 | @ Stephen F. Austin State (Game 1) | Angelina JC, Lufkin | 2-3 L | Recap | Box | | Mar. 10, 2010 | @ Stephen F. Austin State (Game 2) | Angelina JC, Lufkin | 0-2 L | Recap | Box | | Mar. 19, 2010 | Sacred Heart (Coastal Carolina Classic) | Conway, S.C. | 1-2 L | Recap | Box | | Mar. 19, 2010 | Oakland (Coastal Carolina Classic) | Conway, S.C. | 1-2 L | Recap | Box | | Mar. 20, 2010 | Buffalo (Coastal Carolina Classic) | Conway, S.C. | 5-2 W | Recap | Box | | Mar. 20, 2010 | @ Coastal Carolina (Coastal Carolina Classic) | Conway, S.C. | (5 inn.) 0-17 L | Recap | Box | | Mar. 21, 2010 | Buffalo (Coastal Carolina Classic) | Conway, S.C. | 3-0 W | Recap | Box | | Mar. 24, 2010 | Sam Houston State (Game 1) | Husky Field | (6 inn.) 1-0 W | Recap | Box | | Mar. 26, 2010 | Utah Valley (Game 1)* | Farmers Branch | 1-4 L | Recap | Box | | Mar. 26, 2010 | Utah Valley (Game 2)* | Farmers Branch | 3-4 L | Recap | Box | | Mar. 27, 2010 | North Dakota (Game 1)* | Farmers Branch | 6-3 W | Recap | Box | | Mar. 27, 2010 | North Dakota (Game 2)* | Farmers Branch | (8 inn.) 4-3 W | Recap | Box | | Mar. 28, 2010 | South Dakota (Game 1)* | Farmers Branch | 1-2 L | Recap | Box | | Mar. 28, 2010 | South Dakota (Game 2)* | Farmers Branch | 0-1 L | Recap | Box | | Mar. 31, 2010 | Prairie View A&M (Game 1) | Husky Field | (5 inn.) 9-0 W | Recap | Box | | Mar. 31, 2010 | Prairie View A&M (Game 2) | Husky Field | 1-0 W | Recap | Box | | Apr. 6, 2010 | Texas Southern (Game 1) | Husky Field | (9 inn.) 5-3 W | Recap | Box | | Apr. 6, 2010 | Texas Southern (Game 2) | Husky Field | (8 inn.) 6-7 L | Recap | Box | | Apr. 7, 2010 | @ Sam Houston State (Game 1) | Huntsville | Postponed | Recap | Box | | Apr. 7, 2010 | @ Sam Houston State (Game 2) | Huntsville | Postponed | Recap | Box | | Apr. 10, 2010 | @ UH-Victoria (Game 1) | Victoria | 4-5 L | Recap | Box | | Apr. 10, 2010 | @ UH-Victoria (Game 2) | Victoria | 4-2 W | Recap | Box | | Apr. 14, 2010 | @ UTSA (Game 1) | San Antonio | (6 inn.) 0-8 L | Recap | Box | | Apr. 14, 2010 | @ UTSA (Game 2) | San Antonio | 2-5 L | Recap | Box | | Apr. 17, 2010 | Texas Southern (Game 1) | Husky Field | 0-1 L | Recap | Box | | Apr. 17, 2010 | Texas Southern (Game 2) | Husky Field | 3-0 W | Recap | Box | | Apr. 21, 2010 | UTSA (Game 1) | Husky Field | 1-3 L | Recap | Box | | Apr. 21, 2010 | UTSA (Game 2) | Husky Field | 1-4 L | Recap | Box | | Apr. 24, 2010 | Texas A&M-Corpus Christi (Game 1) | Husky Field | 0-6 L | Recap | Box | | Apr. 24, 2010 | Texas A&M-Corpus Christi (Game 2) | Husky Field | (5 inn.) 8-0 W | Recap | Box | | Apr. 28, 2010 | @ McNeese State (Game 1) | Lake Charles, La. | 1-6 L | Recap | Box | | Apr. 28, 2010 | @ McNeese State (Game 2) | Lake Charles, La. | 0-3 L | Recap | Box | | May 16, 2010 | South Dakota (Great West Tournament) | Farmers Branch | 5-7 L | Recap | Box | | May 16, 2010 | Utah Valley (Great West Tournament) | Farmers Branch | 2-5 L | Recap | Box |
| | Record: 16-30 (2-4 conference) Home events are in bold. * - indicates conference event All times are Central Time Zone. |
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